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ARAVA is indicated in adults to the treatments for active rheumatism (RA):


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Take this medicine only as directed by your doctor. Do not take a greater portion of it, do not take on it more often, and do not take it for a longer period than your medical professional ordered.

The dose of the medicine will be different for several patients. Follow your physician's orders or even the directions on the label. The following information includes merely the average doses of this medicine. If your dose differs, don't change it out unless a medical expert notifys you to do this.

The level of medicine that you simply take depends about the strength with the medicine. Also, the volume of doses you are taking each day, the time allowed between doses, as well as the period of time you are taking the medicine depend around the medical problem that you are choosing the medicine.

For oral dosage form (tablets):

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For arthritis rheumatoid:

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If you miss a dose with this medicine, take it as soon as possible. However, when it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions permitted 15-30°C (59-86°F). Protect from light. Keep out in the reach of children. Do not keep outdated medicine or medicine don't needed. Store the medicine in a very closed container at room temperature, far from heat, moisture.

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 Keep out from the reach of kids. Do not keep outdated medicine or medicine no longer needed. Store the medicine in the closed container at room temperature, away from heat, moisture.

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Side Effects

Stop using this medicine and appearance with your doctor straight away if you are having burning, numbness, tingling, or painful sensations inside arms, hands, legs, or feet. These could be signs of a condition called peripheral neuropathy.

Adverse reactions associated with the use of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along with its needed effects, medication might cause some uncomfortable side effects. Although not these unwanted side effects may occur, when they do occur they might need medical attention.

Check with a medical expert immediately if any with the following unwanted side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss in appetite
sore throat
tightness inside the chest
yellow eyes or skin
Less common
Burning feeling in the chest or stomach
burning, prickling, or tingling sensation within the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
difficulty breathing
tenderness within the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening with the skin
blood inside the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general feeling of tiredness or weakness
high fever
large, hive-like swelling around the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
lower back or side pain
pains within the stomach, side, or abdomen, possibly radiating for the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red wounds, often having a purple center
red, irritated eyes
sores, ulcers, or white spots inside mouth or for the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness in the arms, hands, legs, or feet

Some unwanted effects may occur that always don't need medical assistance. These side effects may go away during treatment as your body adjusts towards the medicine. Also, your health care professional could possibly inform you of approaches to prevent or reduce some of these unwanted side effects. Check using your health care professional if any of the following side effects continue or are bothersome or if you've got any queries about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness in the mouth
itching of the skin
pain or burning inside the throat
runny nose

Other side effects unlisted could also appear in some patients. If you notice every other effects, check along with your healthcare professional.



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It is essential that your doctor check your progress at regular visits to be sure that this drugs are functional. Blood tests are usually necesary to check for negative effects.

Using this medicine while you are pregnant may damage your developing fetus. Use an effective kind of contraception to hold from conceiving a child. If you think you might have get pregnant when using the medicine, tell a medical expert without delay.

Leflunomide can also cause birth defects in the event the father is applying it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as a way of birth control method during sexual intercourse. A man aiming to father a youngster should stop using this medicine and appearance together with his doctor immediately.

Serious skin reactions may appear using this medicine. Stop by using this medicine and look with your physician without delay if you might have any in the following symptoms while using this medicine: blistering, peeling, or loosening from the skin; chills; itching; joint or muscle pain; red wounds, often using a purple center; sores, ulcers, or white spots inside the mouth or on the lips; or unusual tiredness or weakness.

Liver problems may occur while you are using this medicine. Stop using this medicine and appearance with a medical expert right away should you be having more than one of the symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; lack of appetite; nausea / vomiting; skin rash; swelling in the feet or legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the number of white blood cells with your blood, helping the probability of getting disease. It can also lower the volume of platelets, that happen to be essential for proper blood clotting. If this occurs, a number of precautions you can take, especially when your blood count is low, to reduce the potential risk of infection or bleeding:

Check with a medical expert without delay if you've a cough with or without a fever, breathlessness, or any difficulty with breathing.

You will need to have a skin test for tuberculosis before you start employing this medicine. Tell your doctor should you or anyone inside your home has ever had a good response to a tuberculosis test.

Using this medicine may improve your risk of getting serious infections or cancer. Talk to your physician if you've concerns about this risk.

Do not take other medicines unless they are discussed with a medical expert. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or nutritional vitamin supplements.

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