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Baclofen is used for treating spasm of skeletal muscles that create muscle clonus, rigidity, and pain because of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also referred to as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to talk together. GABA released by some nerves causes the activity of other nerves to decrease. It is thought that Baclofen, acting like GABA, blocks the game of nerves from the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.

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The usual starting dose of Baclofen for adults is 5 mg thrice daily. Based on the response, the dose could be increased gradually every three days with a maximum of 80 mg/day in numerous doses.

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Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of children.

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Baclofen may cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low hypertension, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

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Abrupt discontinuation of oral Baclofen could potentially cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).

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Use of Baclofen to drugs this depress the function of nerves may lead to additional decrease in brain function.

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In addition towards the probability of depressing brain function, using Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could cause muscle weakness.

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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may result in greater depression of brain function in addition to low blood pressure levels.

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As Baclofen can increase blood glucose, doses of antidiabetic drugs might need to be adjusted when Baclofen is taken.

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The using Baclofen by pregnant women has not been evaluated.

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Baclofen can be detected within the breast milk of mothers taking oral Baclofen. No facts are entirely on the presence of Baclofen within the breast milk of mothers receiving Baclofen intrathecally.

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