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Uses

INDICATIONS

Chloroquine is indicated for your suppressive treatment and for acute attacks of malaria because of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated to the treating extraintestinal amebiasis.

INSTRUCTIONS

Take chloroquine with meals or milk to reduce stomach upset, unless otherwise directed through your doctor.

t is vital that you simply take chloroquine only as directed. Do not take more of it, don't take on it more regularly, and don't take on it much more time than your physician ordered. To do so might increase the potential for serious unwanted side effects.

If you're taking chloroquine to help keep you from getting malaria, keep taking it for your full-time of treatment. If you currently have malaria, you ought to still keep taking chloroquine for that full-time of treatment in case you set out to feel better after a couple of days. This will help to clear up your infection completely. If you stop taking chloroquine prematurily ., your symptoms may return.

Chloroquine is ideal whenever you go on it on the regular schedule. For example, in case you are to go on it once per week to prevent malaria, it's always best to go on it on the same day weekly. Or if you're to take two doses a day, one dose might be taken with breakfast and the other using the evening meal. Make sure that you don't miss any doses. If you might have questions about it, talk with your quality of life care professional.

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If you miss a dose of chloroquine, go as soon as possible. However, if it is almost time for your next dose, skip the missed dose and get back to your regular dosing schedule. Do not double doses.

DOSAGE 

The dosage of chloroquine phosphate can often be expressed with regards to equivalent chloroquine base. Each 500 mg tablet of ARALEN offers the same in principle as 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body mass.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on exactly the same day of each week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of bodyweight, but shouldn't exceed the adult dose irrespective of weight.

If circumstances permit, suppressive therapy should start a fortnight prior to exposure. However, failing this in older adults, an initial double (loading) dose of just one g (= 600 mg base), or in children 10 mg base/kg might be used two divided doses, six hours apart. The suppressive therapy must be continued for two months after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of 1 g (= 600 mg base) accompanied by an additional 500 mg (= 300 mg base) after six to eight hours and a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents a complete dose of 2.5 g chloroquine phosphate or 1.5 g base in three days.

The dosage for adults of low body weight as well as for infants and children needs to be determined as follows:

First dose: 10 mg base per kg (although not exceeding an individual dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding an individual dose of 300 mg base).

Third dose: (one day after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with the 8-aminoquinoline compound is necessary.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two days, followed by 500 mg (300 mg base) daily for about two to three weeks. Treatment is usually combined with the effective intestinal amebicide.

STORAGE 

Store the medicine in a very closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of your reach of youngsters.

Do not keep outdated medicine or medicine don't needed.

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Side Effects

Along using its needed effects, medicine may cause some negative effects. Although not many of these unwanted side effects may occur, should they occur they may need medical attention. When chloroquine is utilized abbreviated durations, side effects usually are rare. However, when it is used for a long time and/or perhaps in high doses, negative effects will occur and may be serious.

Check with your physician immediately if the following unwanted side effects occur:
Less common

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Blurred vision
change in vision
eye pain
lack of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood and other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any loss in hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The negative effects inside Less Common category above can also occur or worsen once you stop taking chloroquine.

Some unwanted effects may occur have a tendency to do not need medical attention. These unwanted side effects might go away during treatment since your body adjusts for the medicine. Also, your health care professional could be able to inform you of ways to avoid or reduce a few of these unwanted effects. Check with your quality of life care professional if these things unwanted side effects continue or are bothersome or if you've got questions about them:

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More common


Diarrhea
difficulty in seeing to read
headache
itching (more prevalent in black patients)
decrease of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or in mouth
skin rash

Other side effects unlisted may also appear in some patients. If you notice any other effects, consult your health care professional.

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Precautions

If you'll be taking chloroquine for a long time, it is very important that your physician check you at regular visits for almost any blood problems or muscle weakness that may be due to chloroquine. In addition, consult a medical expert immediately if blurred vision, difficulty in reading, or any other alternation in vision occurs during or after treatment. Your doctor might prefer you to definitely have your eyes checked by an ophthalmologist (eye doctor).

If your symptoms usually do not improve in a couple of days or whenever they become worse, consult your doctor.

Make sure you probably know how you respond to chloroquine before you drive, use machines, or do anything else that is dangerous in case you are not able to see well.

Chloroquine could potentially cause blurred vision, difficulty in reading, or another alteration of vision. It may also cause many people to get lightheaded.

If these reactions are specially bothersome, consult a medical expert.

Certain medicines must not be used at or around the time of consuming food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines can also cause interactions to take place. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

There are not any adequate and well-controlled studies evaluating the security and efficacy of chloroquine in expecting mothers. Usage of chloroquine while pregnant must be avoided except within the suppression or treating malaria when inside the judgment with the physician the advantage outweighs the opportunity risk to the fetus.

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