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Precautions

Do NOT use Depakote if:

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• you are allergic to any ingredient in Depakote
• you've got liver problems or a urea cycle disorder.

Contact your medical professional or physician immediately if some of these connect with you.

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Some medical ailments may interact with Depakote. Tell your medical professional or pharmacist if you have any health concerns, particularly if any in the following apply to you:

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• if you are pregnant, intending to conceive, are breast-feeding

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• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• in case you have allergies to medicines, foods, and other substances
• when you have a history of alcohol abuse, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood numbers of ammonia or glutamine, low temperature, low amounts of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation from the pancreas, kidney problems, or low amounts of white blood cells, or if you are scheduled for surgery

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• for those who have a history of ornithine transcarbamylase deficiency or unexplained coma
• when you have a family good reputation for urea cycle disorders or unexplained infant deaths

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• in case you have a good reputation for mental or mood problems (eg, depression), or suicidal thoughts or actions

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• if you take some other medicine for seizures.

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Some medicines may connect to Depakote. Tell your doctor in case you are taking some other medicines, especially any from the following:

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• Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) for the reason that risk of serious unwanted effects of Depakote, including changes in vision and other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, may be increased

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• Clonazepam since the chance of seizures could be increased

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• Topiramate since the likelihood of high ammonium levels, brain problems, or perhaps an unusual drop in body's temperature might be increased
• Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, contraceptive pills), or rifampin since they may decrease Depakote's effectiveness
• Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine since the chance of their unwanted effects could be increased by Depakote.

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This will not be a whole report on all interactions which could occur. Ask your health care provider if Depakote may talk with other medicines that you're taking. Check with your doctor before starting, stop, or affect the dose from a medicine.

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Important safety information:

• Depakote might cause drowsiness, dizziness, or blurred vision. These effects could possibly be worse in the event you go with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks unless you understand how you respond to it.

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• Do not consume alcohol or use medicines that could cause drowsiness (eg, sleep aids, muscle relaxers) while you're using Depakote; it may enhance their effects. Ask your pharmacist when you have questions regarding which medicines might cause drowsiness.

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• Inflammation in the pancreas is often a potentially life-threatening illness connected with Depakote. Symptoms include stomach pain, vomiting, or loss in appetite. Contact your physician at the same time if any of these symptoms occur.

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• Patients taking Depakote may be at increased risk for suicidal thoughts or actions. The risk might be greater in patients who have had suicidal thoughts or actions inside past. Patients who may have bipolar (manic-depressive) illness could also come with an increased risk for suicidal thoughts or actions. Watch patients taking Depakote closely. Contact your physician simultaneously if new, worsened, or sudden symptoms, like depressed mood; anxious, restless, irritable behavior; panic and anxiety attacks; or any unusual change in mood or behavior occur. Contact the doctor without delay if any signs and symptoms of suicidal thoughts or actions occur.
• Depakote may reduce the amount of clot-forming cells (platelets) inside your blood. Avoid activities that could potentially cause bruising or injury. Tell a medical expert if you have unusual bruising or bleeding. Tell your medical professional in case you have dark, tarry, or bloody stools.

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• Tell a medical expert or dentist that you take Depakote when you have any medical or dental care, emergency care, or surgery.

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• Diabetes patients - Depakote may cause the outcomes of some tests for urine ketones to become wrong. Ask your medical professional before you change your diet or even the dose of the diabetes medicine.

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• Depakote could raise the ammonia levels within your blood. Contact a medical expert right away in the event you experience unexplained sluggishness and vomiting or mental changes.
• Depakote might cause a rare drop in temperature (hypothermia). Symptoms can sometimes include confusion, not enough energy, loss in coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact a medical expert immediately for those who have these symptoms.

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• Depakote may obstruct certain lab tests, including thyroid function. Be sure your medical professional and lab personnel know you are taking Depakote
• Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, could possibly be performed while you use Depakote. These tests could possibly be employed to monitor your trouble or search for negative effects. Be sure to keep all doctor and lab appointments.

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• Use Depakote with caution inside elderly; they may be more responsive to its effects, especially drowsiness.

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• Depakote must be in combination with warning in youngsters younger than 10 years old; safety and effectiveness over these children haven't been confirmed. Children younger 24 months could possibly be at increased chance of serious liver problems.

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• Pregnancy and breast-feeding: Depakote has been shown to damage the fetus. Use an effective form of birth control while you are taking Depakote. If you think you may be pregnant or in case you wish to get pregnant, contact your medical professional. You will need to discuss the rewards and perils of using Depakote when you are pregnant. Depakote can be found in breast milk. Do not breastfeed if you are taking Depakote.

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