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Precautions

Do NOT use Duetact if:

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• you might be allergic to any ingredient in Duetact

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• you've moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems related to diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or extremely high blood acid levels (acidosis)

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• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• in case you have had a serious hypersensitive reaction (eg, severe rash, hives, , etc ., dizziness) to your other sulfonamide medicine such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide

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• when you have a reputation kidney, thyroid, heart, or circulatory problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or lower levels of an enzyme called glucose 6-phosphate dehydrogenase (G6PD)

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• for those who have stomach or irregularity (eg, stomach or bowel blockage, stomach paralysis), consume alcohol, or have had poor nutrition

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Some medicines may communicate with Duetact. Tell your medical provider in the event you take any other medicines, especially any of the following:

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• Bosentan because liver problems may occur, and also the effectiveness of both medicines could be decreased
• Beta-blockers (eg, propranolol) for the reason that chance of low blood sugar levels may be increased. They may also hide certain signs and symptoms of low blood glucose and earn it more challenging to notice

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• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) for the reason that likelihood of low blood glucose levels may be increased

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• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) simply because they may decrease Duetact's effectiveness, producing high blood sugar

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This may not be an entire set of all interactions that will occur. Ask your doctor if Duetact may interact with other medicines that you simply take. Check with your doctor before you start, stop, or customize the dose of the medicine.

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Important safety information:

• Duetact could potentially cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects could be worse if you get it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

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• Do not are drinking alcohol while you are taking Duetact; it could boost the risk of low blood glucose. Rarely, alcohol may communicate with Duetact and spark a serious reaction with symptoms for example flushing, nausea, vomiting, dizziness, or stomach pain. Discuss questions or concerns using your doctor.

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• Duetact could potentially cause low blood sugar levels. Low blood glucose levels may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; build your vision change; give you a headache, chills, or tremors; or allow you to more hungry. It is a good plan to handle a dependable method to obtain glucose (eg, tablets or gel) to deal with low blood glucose. If this is not available, you should eat or drink a fast source of sugar like ordinary sugar, honey, candy, orange juice, or non-diet soda. This will lift up your blood sugar levels level quickly. Tell your physician right away if this happens. To prevent low blood sugar levels, eat meals concurrently every day , nor skip meals.
• Risk of low blood sugar levels could be increased by severe or prolonged exercise, drinking alcohol, or skipping meals.
• Duetact posesses a sulfonylurea. It may improve the chance of death from coronary disease. Talk using your doctor regarding the benefits and perils of this or other therapies to deal with your condition.

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• Lab tests, including fasting blood sugar levels, hemoglobin A_1c, liver function, and eye exams, may be performed as you use Duetact. These tests might be used to monitor your problem or check for unwanted side effects. Be sure to keep all doctor and lab appointments.

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• Use Duetact with caution in the elderly; they may be more responsive to its effects, especially the probability of cardiovascular disease or low blood sugar levels.

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• Pregnancy and breast-feeding: Duetact might cause problems for the fetus or newborn. If you think you could possibly be pregnant, get hold of your doctor. You will need to discuss the benefits and perils of using Duetact while you are pregnant. It is not known if Duetact is located in breast milk. Do not breastfeed while taking Duetact.

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When used by long periods of time Duetact might not exactly are well. If your blood glucose may be manageable after which becomes hard to manage, get hold of your doctor. Do not customize the dose of your medicine without checking using your doctor.

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