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Uses

INDICATIONS

Indinavir is definitely an antiviral medication inside a gang of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within your body. It is employed to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is just not a cure for HIV or AIDS.

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INSTRUCTIONS

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Take indinavir exactly as it turned out prescribed to suit your needs. Do not consider the medication in larger amounts, or take it more than recommended by your doctor. Follow the directions in your prescription label.

This medication includes patient instructions for secure and efficient use. Follow these directions carefully. Ask your medical professional or pharmacist for those who have any questions.
Take indinavir with a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea using this medication. Drink at the very least 6 glasses of water each day in order to avoid kidney stones when you are taking indinavir. Indinavir ought to be taken on jail stomach, a minimum of an hour before or a couple of hours from a meal.

If you'd like to take the medication with food, eat merely a light meal, such as dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is very important to work with indinavir regularly to get the most benefit. Get your prescription refilled before you run out of medication completely.

To be sure medicines is helping your condition, your blood will have to be tested often. Your liver function might also need to be tested. Do not miss any scheduled visits to your medical professional.

HIV/AIDS is usually treated having a combination of different drugs. To best treat your complaint, make use of all of one's medications as directed through your doctor. Be sure to look at medication guide or patient instructions provided with each of one's medications. Do not alter your doses or medication schedule without advice from your medical professional. Every person with HIV or AIDS should remain beneath the care of a physician.

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Take the missed dose whenever you remember and take your following dose with the regularly scheduled time. If you are a lot more than a couple of hours late in taking your indinavir, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to create up the missed dose.

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DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.

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Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis ought to be initiated as soon as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is among the alternative regimens suitable for nonoccupational postexposure HIV prophylaxis.

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Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy has to start promptly, preferably within 1 to 120 minutes postexposure. The exact duration of therapy could differ using the institution's protocol.

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Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider lowering the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is given concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence to the prescribed dose is essential. Patients shouldn't affect the dose or discontinue therapy without conferring with their physician.

Adequate hydration (1.5 liters/day) is important during therapy to lessen the chance of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation may be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

STORAGE

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Store indinavir at room temperature faraway from moisture and heat. Keep the capsules inside their original container, along with the packet of moisture-absorbing preservative that comes with indinavir capsules.

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Side Effects

Get emergency medical help if you have any of these signs and symptoms of a hypersensitive reaction: hives; breathlessness; swelling of the face, lips, tongue, or throat. Stop taking indinavir and call your doctor at the same time if you have all of these serious unwanted effects:

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Less serious unwanted side effects may include:

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This is not a complete set of negative effects and others may occur. Tell your physician about any unusual or bothersome complication.

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Precautions

Do not take this medication if you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines like ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs might cause life-threatening unwanted effects if you are using them while you're taking indinavir.

Before taking indinavir, tell your doctor if you are allergic to your drugs, or if you have:

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If you've these conditions, you need a dose adjustment or special tests to securely take indinavir.
FDA pregnancy category C. This medication could possibly be harmful to an developing fetus. Tell your medical professional if you're pregnant or intend to get pregnant during treatment. HIV may be passed to the baby if the mother just isn't properly treated while pregnant. Take all of the HIV medicines as given to overcome your infection while you're pregnant.

Your name may need to be from an antiviral pregnancy registry when you start using this medication.
You should not breast-feed while you're using indinavir. Women with HIV or AIDS must not breast-feed whatsoever. Even if baby comes into the world without HIV, you may still pass the virus on the baby inside your breast milk.

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