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Uses

INDICATIONS

Indinavir is definitely an antiviral medication in a very band of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within you. It is utilized to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Indinavir is just not a cure for HIV or AIDS.

INSTRUCTIONS

Take indinavir the same manner it turned out prescribed for you personally. Do not go ahead and take medication in larger amounts, or go on it more than recommended because of your doctor. Follow the directions on your prescription label.

This medication is sold with patient instructions for secure and efficient use. Follow these directions carefully. Ask a medical expert or pharmacist in case you have any questions.
Take indinavir which has a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea with this medication. Drink at least 6 servings of water on a daily basis to prevent kidney stones while you're taking indinavir. Indinavir should be taken on a clear chair stomach, at least one hour before or a couple of hours after a meal.

If you prefer to make medication with food, eat merely a light meal, including dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is vital to use indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure medicines helps your problem, your blood will have to be tested often. Your liver function may also have to be tested. Do not miss any scheduled visits to your medical professional.

HIV/AIDS is generally treated with a combination of different drugs. To best treat your complaint, utilise all of one's medications as directed from your doctor. Be sure to see the medication guide or patient instructions supplied with each of your respective medications. Do not change your doses or medication schedule without advice from your physician. Every person with HIV or AIDS should remain beneath the proper care of a physician.

Take the missed dose as soon as you remember and take your next dose on the regularly scheduled time. If you are more than a couple of hours late in taking your indinavir, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis needs to be initiated at the earliest opportunity, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is probably the alternative regimens appropriate for nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy should start promptly, preferably within 1 to a couple of hours postexposure. The exact amount of therapy may vary in line with the institution's protocol.

Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider lowering the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin emerges concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence on the prescribed dose is crucial. Patients should not modify the dose or discontinue therapy without consulting their physician.

Adequate hydration (1.5 liters/day) is vital during therapy to lessen potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation might be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

STORAGE

Store indinavir at room temperature faraway from moisture and heat. Keep the capsules within their original container, combined with the packet of moisture-absorbing preservative that incorporates indinavir capsules.

Side Effects

Get emergency medical help for those who have some of these signs of a hypersensitivity: hives; breathlessness; swelling of your respective face, lips, tongue, or throat. Stop taking indinavir and call your doctor at the same time if you have some of these serious side effects:

Less serious negative effects can include:

This is just not a complete listing of unwanted side effects and others may occur. Tell your medical professional about any unusual or bothersome side effect.

Precautions

Do not take this medication in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines for example ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs might cause life-threatening side effects if you utilize them if you are taking indinavir.

Before taking indinavir, tell your medical professional if you're allergic to the drugs, or when you have:

If you might have these conditions, you might need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication could be damaging to an developing fetus. Tell your medical professional if you're pregnant or want to get pregnant during treatment. HIV could be passed on the baby when the mother just isn't properly treated when pregnant. Take all of your respective HIV medicines as given to overcome your infection if you are pregnant.

Your name may need to be listed on an antiviral pregnancy registry once you begin using prescription drugs.
You should not breast-feed if you are using indinavir. Women with HIV or AIDS must not breast-feed at all. Even if your baby comes into the world without HIV, you may still pass the herpes simplex virus for the baby with your breast milk.


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