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Uses

INDICATIONS

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Meldonium treats heart ischemia and its particular consequencesis.  It is employed in the management of brain circulation disorders. Meldonium is assumed to enhance Mental Processes (Memory, Learning, Focus, Concentration, Processing of Information) and reduces Fatigue, Increases Motivation & Alertness. Meldonium was made to enhance Athletic Training & Competitive Performance at the same time as microcirculation & Oxygen Delivery.

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Due to its unique mechanism of action Mildronate, with regards to the prescribed dose, is traditionally used for the treatment of different heart and vascular diseases, at the same time as for that improvement at work capacity of healthy people at physical and mental overloads and during rehabilitation period.

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INSTRUCTIONS

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Applied internally.

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• Intellectual and physical stress (including in athletes). Adults – 1 g each day
divided into two 500mg doses. Course of treatment is 10-14 days. If necessary, the treatment is repeated in 2-3 weeks.

• Athletes should take 500 mg – 1 g two times a day before training. Duration of
treatment during preparatory period is 2-3 weeks, throughout competition – 10-14 days.

• Cardiovascular disease. As part of combined therapy: 500 mg -1 g (1-2 tablets) per day, using the whole dose previously or dividing for just two takings. Course of treatment is 4-6 weeks.

• Cardialgia from the background of dyshormonal myocardiodystrophy – 500 mg per day. Course of treatment is 12 days.

• Disturbed cerebral circulation. In course of treatment after reduction of acute disorders: 500 mg – 1 g each day, using whole dose at one time or dividing it for 2 takings. In case of chronic disorders: 500 mg daily. General course of treatment is 4-6 weeks. Recurrent courses (usually 2-3 times a year) might be taken after consulting a physician.

• Diseases of peripheral arteries. 500 mg twice a day.

• Abstinence syndrome in the event of chronic alcoholism. 500 mg four times each day. Course of treatment is 7-10 days.

• Maximum daily dose is 2000 mg.

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Please speak to your physician prior to by using this or another vitamins and minerals or medications.

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DOSAGE

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Please consult a physician concerning the required dosage.

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Overdosage
There is not any data of cases of Meldonium overdosage. The drug is low-toxic.

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STORAGE 

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Keep from direct sunlight.
Keep locked and away from children.
Store in dry place at room temperature.
Do not exceed storage temperature greater than 25 C

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Side Effects

Rarely - hypersensitive reactions (redness, rash, itching, oedema), also as dyspepsia, tachycardia, excitement, changes of arterial pressure.

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Precautions

Contraindications:

Hypersensitivity, increased intracranial pressure (in violation from the venous outflow, intracranial tumors).

Restrictions:

Pregnancy, lactation, children under 18 (capsule, injectable solution) or 12 years (syrup), since safety and efficacy haven't been determined.

Pregnancy and breast-feeding:

Not recommended in pregnancy (safety haven't been proven). At the time of treatment should stop breastfeeding (known whether or not the breast milk gets).

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Interaction with other drugs and also other forms of interaction

The drug may be along with antianginal agents, anticoagulants and antiaggregants, antiarrhythmic drugs, diuretics, and bronchial spasmolytics. It intensifies the action of coronary vasodilating drugs, some hypotensive agents, and cardiac glycosides. Taking into consideration the possible growth and development of mild tachycardia and arterial hypotension, care must be taken when combining the drug with nitroglycerin, nifediphine, alpha-adrenoceptor blockers, hypotensive agents and peripheral vasodilators.

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